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Keep an eye on Closely (1)pentobarbital will minimize the level or result of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a minimize in fentanyl plasma concentrations, lack of efficacy or, perhaps, enhancement of the